Use of inhaled nitric oxide in pediatric cardiac intensive care unit.

[Inhaled nitric oxide in pediatrics].

OBJECTIVE To review the literature on inhaled nitric oxide and to describe its main clinical applications in pediatrics. SOURCE OF DATA A 10 year literature review with selection of the most important publications on inhaled nitric oxide, using the Medline and Cochrane Systematic Review databases. SUMMARY OF THE FINDINGS This review was organized as follows: introduction; metabolism and bio...

Inhaled iloprost for the control of acute pulmonary hypertension in children: a systematic review.

OBJECTIVE Inhaled iloprost is attracting growing interest as a potential alternative and/or adjuvant to inhaled nitric oxide in the management of pediatric pulmonary hypertension in the acute and intensive care settings. However, there are currently no formal evidence-based guidelines regarding the use of inhaled iloprost in children with pulmonary hypertension. The aim of this systematic revie...

Acute and sustained effects of early administration of inhaled nitric oxide to children with acute respiratory distress syndrome.

OBJECTIVE To determine the acute and sustained effects of early inhaled nitric oxide on some oxygenation indexes and ventilator settings and to compare inhaled nitric oxide administration and conventional therapy on mortality rate, length of stay in intensive care, and duration of mechanical ventilation in children with acute respiratory distress syndrome. DESIGN Observational study. SETTIN...

A European survey of the use of inhaled nitric oxide in the ICU. Working Group on Inhaled NO in the ICU of the European Society of Intensive Care Medicine.

Inhaled nitric oxide as a selective pulmonary vasodilator in clinical anesthesia.

Inhaled nitric oxide (NO) is a selective pulmonary vasodilator in adult and pediatric patients. Inhaled NO diffuses into the pulmonary vascular smooth muscle where it results in vasodilation via stimulation of guanylyl cyclase. Systemic hemodynamics are not altered because inhaled NO is rapidly inactivated by hemoglobin. Oxygenation is also increased in certain patients as inhaled NO only vasod...